We were excited to meet with and interview Ronen Jashek from Theranica, makers of Nerivio. What we love about the Nerivio device is that it’s worn on the upper arm and not on the head, so it can be a more discreet option. If you read to the end of the interview you will find my review of the Nerivio device and how it has worked for me! – Grace from Innovation in Migraine
What is Nerivio?
Our first product, Nerivio, is an innovative FDA-authorized, non-invasive, smartphone-operated, prescribed wearable for the acute treatment of migraine in patients 12 years of age or older. In November 2019 Nerivio was named one of TIME’s 100 Best Inventions of the year under the healthcare category.
Nerivio was evaluated in several clinical studies. The first study was a prospective, double-blind, randomized, crossover, sham-controlled pilot study and the second study was a multi-center, prospective, randomized, double-blind, sham-controlled pivotal study.
How does it work?
Nerivio stimulates small nerves in the upper arm. The message from the arm is received by a brainstem pain regulation center that can inhibit pain signals by releasing neurotransmitters, resulting in significant pain relief which can end the migraine attack. The process is illustrated in the following image:
Can you share some information on the efficacy of Nerivio?
Sure – Nerivio was evaluated in five clinical studies. The first study was a prospective, double-blind, randomized, crossover, sham-controlled pilot study and the second study was a multi-center, prospective, randomized, double-blind, sham-controlled pivotal study.
The other two studies were prospective, open label studies that evaluated the safety and efficacy of the Nerivio device in patients with chronic migraines (>15 headache days/month).
Lastly, Nerivio was also studied with adolescents migraine patients. The study was a prospective, open-label, single arm, multicenter study of the Nerivio device in adolescent patients (age 12-17, inclusive), aiming to assess the performance of Nerivio in the adolescent migraine population.
How is Nerivio innovative?
Nerivio encompasses the best elements of MedTech solutions, including a digital health, non-invasive treatment approach that deploys an innovative mechanism of action and an accompanying smartphone app that allows patients to control the device while enabling easy tracking and management of their migraines.
Nerivio is placed on the upper arm and uses remote electrical neuromodulation (REN) to stimulate the brain’s native pain inhibition mechanism known as Conditioned Pain Modulation (CPM). Combining this advanced neuromodulation therapy with wireless technology, Nerivio is clinically proven and FDA-cleared for the acute treatment of both episodic and chronic migraine and is a drug-free alternative to traditional migraine treatments.
What is Theranica’s vision for people living with migraine?
We envision MedTech line of products that will allow people living with migraine to treat their migraines quickly, conveniently, discreetly while keeping their daily routines, without the need to overwhelm their body with drugs and medications, and to suffer from their side effects.
What other innovations or research in migraine are you really excited about at the moment?
We are excited about the opportunity to combine migraine treatment with behavioral tools that allow people living with migraine to better control their condition and enjoy a healthier lifestyle.
If you could share one message about migraine to the wider community, what would it be?
That we hear your call! We are on a mission to help you treat your migraines in the most effective and non-intrusive way!
Innovation in Migraine Review!
Everyone’s experience with treatments is unique, just because something works or doesn’t work for me, does not mean the same for you. Always work with a doctor or healthcare professional to determine what is right for you.
Overall I’d rate the device: 7/10
Summary: Nerivio provided pain relief while I was using it but didn’t provide me with lasting relief from pain or symptoms .
My first impressions were of the packaging, device, armband and travel pouch which I thought were very well designed and nice to look at. It doesn’t have the look or feel of anything you’d find in a doctor’s office which is comforting.
When I was ready for a session, I found the app easy to set up and the device simple to put on. I didn’t ramp up the intensity on the first session too much, I wanted to get used to the sensation on my arm first. At lower intensities, I had no issue with the sensation and had undesirable effects. When I went up to higher intensities on later sessions, I found that I had muscle twitching throughout my arm.
I found that my level of pain was reduced when the device was running but it did not seem to help the photophobia which I had during the attacks.
I would have loved the Nerivio more if my pain seemed to completely disappear while using the device, but that hasn’t happened yet. I did not receive any lasting effects of the treatments unfortunately either.
The app has a guided imagery video/ audio track that you can play while the treatment is running which I really enjoyed. This was very calming and reminded be a bit of some of the visualisations on the Curable App.
I have used the Nerivio device several times now and find myself reaching to use it if I can feel an attack just beginning during the day (if it’s at night I’d rather use the 20min cefaly session and try to go to sleep because 45mins is quite long).
Overall, I like using the Nerivio device and I’m happy to have another non-medication option in my migraine toolkit – especially one that is a bit more discreet.