We are committed to sharing the latest and most innovative evidence based tools and treatments for migraine. This list covers devices, applications, medications and specific tools for specific symptoms. Please be patient while we continue to build out this list and feel free to send any suggestions to innovationinmigraine@gmail.com. Please consult a headache specialist or neurologist where possible to seek advice on what treatments and tools are suitable for you.
Electronic Devices
Nerivio
Nerivio is a remote electrical neuromodulation (REN) device which is worm on the upper arm and works to include conditioned pain modulation which helps help to inhibit pain in other areas of the body. It has been approved to treat migraine. https://nerivio.co/
gammaCore
gammaCore is a device that has been approved to treat migraine using non-invasive vagus nerve stimulation which is theorised to block the pain signal that cause migraine attacks. https://www.gammacore.com/
Cefaly
Cefaly is approved for preventing and treating migraine attacks. It is an External Trigeminal Nerve Stimulation device (e-TNS), which means that it send electrical signals to stimulate the trigeminal nerve through the device attached to an electrode on your forehead. https://www.cefaly.com/
sTMS Mini
The sTMS mini by eNeura is a clinically proven device that uses a single pulse of transcranial magentic stimulation to provide relief from migraine in a portable device. https://www.eneura.com/
Apps
Ctrl M
Ctrl M is an application that provides a customised plan with positive lifestyle changes that can help you improve the management of migraine. It has been developed in collaboration with the Jefferson Headache Center in Philadelphia. https://ctrlmhealth.com/
N1-HeadacheTM
N1-HeadacheTM is an app that allows patients to track their migraine attacks and triggers and provides personalised advice to patients as well as real time data and insights to clinicians managing the patient’s care. https://n1-headache.com/
Migraine Buddy
Migraine Buddy is the most popular migraine attack tracking app. It allows you to capture and track an extensive list of symptoms, triggers and reliefs and provides access to useful reporting to share with your doctors. It also has community chat functions and migraine information. https://migrainebuddy.com/
Curable
Curable is an app that uses pain science and research to provide lessons on chronic pain as well as exercises that allow you to understand what may be contributing to you pain and symptoms. The app also provides several visualisations to assist users when they are experiencing a flare or high pain. https://www.curablehealth.com/
Light Sensitivity (Photophobia)
Avulux
Avulux is a medical device that uses patented technology to filter out the bands of light that are most painful for people with migraine. Both frequency of migraine attacks and light sensitivity are shown to be improved. https://avulux.com/
Allay Lamp
The Allay Lamp uses a very narrow spectrum of light that has been shown to be reduce migraine symptoms during an attack. This lamp can provide a non-irritating source of light as well as work to decrease symptoms. https://allaylamp.com/
Neurology Services
Cove
“An online doctor visit designed by headache experts”. Cove is an online service that allows you to work with a neurologist and access treatment options at an affordable price. They have recognised that there is a dramatic shortage of headache specialists in the US, and have found a solution so that many more people with migraine can access treatment. https://www.withcove.com/
Medications
Please note that in this section we are only including medications that have been designed to treat or prevent migraine, and does not represent the full list of treatment options available to people living with migraine.
Acute Medications (to treat an attack)
Triptan Class
“Triptans are considered selective serotonin receptor agonists, meaning that triptans work by stimulating serotonin, a neurotransmitter found in the brain, to reduce inflammation and constrict blood vessels, thereby stopping the headache or migraine.” – National Headache Foundation
- Sumatriptan (Known as Imitrex or Imigran)
- Zolmitriptan (Known as Zomig)
- Naratriptan (Known as Amerge)
- Rizatriptan (Known as Maxalt)
- Almotriptan (Known as Axert)
- Eletriptan (Known as Relpax)
- Frovatriptan (Known as Frova)
Ditan Class
Ditans work similarly to triptans but bind to a single serotonin receptor and are thought to show less side effects related to vasoconstriction.
- Lasmiditan (Known as Reyvow)
Gepant Class
Gepants work by blocking the release of calcitonin gene related peptide (CGRP) at the receptor. CGRP has been implicated in the pathophysiology of migraine. Gepants are design to work in an acute setting and different from the CGRP monoclonal antibodies approved from preventative treatment.
- Rimegepant (Known as NurTec ODP)
- Ubrogepant (Known as Ubrelvy)
Prophylactic Medications (to prevent an attack)
CGRP Monoclonal Antibodies
Calcitonin Gene Related Peptide (CGRP) monoclonal antibodies work by either acting on the CGRP itself or working at the receptor of the CGRP. In both cases, they prevent the normal action of CGRPs and have been shown to be effective in preventing migraine attacks.
- Galcanezumab (Known as Emgality) (targets CGRP itself)
- Erenumab (Known as Aimovig) (targets CGRP receptor)
- Fremanezumab (Known as Ajovy) (targets CGRP itself)
- Eptinezumab (Known as Vyepti) (targets CGRP itself)
Innovation in Migraine 